Gynaecology SACT regimens:

Whilst every effort is made to ensure the accuracy of the information in a given regimen it cannot be guaranteed that the regimen is fully up to date, because of the dynamic nature of cancer treatment. Check the regimen details for the specific indication the regimen may be used / funded in. See our disclaimer.

Thames Valley have agreed that an H₂ antagonist is no longer required as premedication before paclitaxel doses.
Therefore H₂ antagonist premedication may be omitted from paclitaxel regimens.

Paclitaxel may be administered via a DEHP free line instead of the polyethylene lined giving set specified in the regimens.

Cervix

• Bevacizumab (15mg/kg) Paclitaxel Carboplatin
• Bevacizumab Pembrolizumab Carboplatin Paclitaxel
• Carboplatin Etoposide
• Cisplatin (40) with concurrent RT
• Cisplatin Etoposide with concurrent RT
• Paclitaxel Carboplatin
• Paclitaxel weekly Carboplatin weekly
• Paclitaxel weekly Carboplatin weekly Cisplatin with concurrent RT
• Pembrolizumab Carboplatin Paclitaxel 

Endometrial

• Carboplatin
• Cisplatin (50) with concurrent RT – local funding
• Dostarlimab
• Dostarlimab Carboplatin Paclitaxel
• Lenvatinib Pembrolizumab
• Liposomal doxorubicin
• Liposomal doxorubicin Carboplatin
• Paclitaxel (3 weeks on 1 week off)
• Paclitaxel Carboplatin

Ovarian / Uterine

• Bevacizumab (7.5mg/kg) Paclitaxel Carboplatin
• Bevacizumab (15mg/kg) Paclitaxel Carboplatin
• Bevacizumab maintenance
• Carboplatin
• Carboplatin desensitisation
• Cisplatin Etoposide (oral)
• Cisplatin (60)
• Cisplatin (100)
• Etoposide (IV)
• Etoposide (oral)
• Gemcitabine Carboplatin
• Gemcitabine Cisplatin
• Liposomal doxorubicin
• Liposomal doxorubicin Carboplatin
• Niraparib (1st line maintenance)
• Niraparib (relapsed) (2nd or subsequent line maintenance)
• Olaparib
• Olaparib Bevacizumab
• Paclitaxel
• Paclitaxel weekly
• Paclitaxel (3 weeks on 1 week off)
• Paclitaxel Carboplatin
• Paclitaxel Cisplatin
• Paclitaxel weekly Carboplatin
• Paclitaxel weekly Carboplatin weekly
• Rucaparib
• Trametinib

Vulva / Vagina

• Cisplatin (40) with concurrent RT
• Paclitaxel Carboplatin

Gestational trophoblastic disease

• EMA / CO
• Methotrexate

Non-seminomatous germ cell tumours

• BEP 3 day adjuvant
• BEP 3 day metastatic
• BEP 5 day metastatic
• POMB ACE

Cisplatin hydration

• Cisplatin hydration

SACT regimens written by S Coutts

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