Upper Gastrointestinal SACT regimens:

Whilst every effort is made to ensure the accuracy of the information in a given regimen it cannot be guaranteed that the regimen is fully up to date, because of the dynamic nature of cancer treatment. Check the regimen details for the specific indication the regimen may be used / funded in. See our disclaimer.

Thames Valley have agreed that an H₂ antagonist is no longer required as premedication before paclitaxel doses.
Therefore H₂ antagonist premedication may be omitted from paclitaxel regimens.

Paclitaxel may be administered via a DEHP free line instead of the polyethylene lined giving set specified in the regimens.

Gallbladder Cholangiocarcinoma

• Capecitabine 
• Durvalumab Gemcitabine Cisplatin
• Gemcitabine (1000) Cisplatin (25)
• Ivosidenib
• Oxaliplatin Modified de Gramont (FolFOx) (local funding)
• Pemigatinib

Gastric

• Docetaxel
• Docetaxel Fluorouracil Oxaliplatin (FLOT)
• Irinotecan Modified de Gramont
• Nivolumab Oxaliplatin Capecitabine
• Nivolumab Oxaliplatin Modified de Gramont
• Oxaliplatin Capecitabine (OX)
• Oxaliplatin Modified de Gramont (FolFOx)
• Paclitaxel Carboplatin
• Pembrolizumab Oxaliplatin Capecitabine
• Pembrolizumab Oxaliplatin Modified de Gramont 
• Trastuzumab Cisplatin Capecitabine
• Trifluridine-tipiracil

Hepatocellular

• Atezolizumab Bevacizumab
• Cabozantinib
• Durvalumab Tremelimumab
• Lenvatinib
• Regorafenib
• Sorafenib

Oesophagus

• Cisplatin Capecitabine
• Cisplatin Capecitabine with concurrent RT
• Cisplatin Fluorouracil (CF80 pre op)
• Cisplatin Fluorouracil with concurrent RT (CF75)
• Docetaxel
• Docetaxel Fluorouracil Oxaliplatin (FLOT)
• Irinotecan Modified de Gramont
• Nivolumab
• Nivolumab Oxaliplatin Capecitabine
• Nivolumab Oxaliplatin Modified de Gramont
• Oxaliplatin Capecitabine (OX)
• Oxaliplatin Modified de Gramont (FolFOx)
• Paclitaxel Carboplatin
• Paclitaxel Carboplatin with concurrent RT
• Pembrolizumab Oxaliplatin Capecitabine
• Pembrolizumab Oxaliplatin Modified de Gramont 
• Trifluridine-tipiracil

Pancreas

• Capecitabine with concurrent RT
• Fluorouracil with concurrent RT
• FOLFIRINOX (metastatic)
• FOLFIRINOX modified (adjuvant) (local funding)
• Gemcitabine
• Gemcitabine Capecitabine
• Gemcitabine Paclitaxel albumin bound
• Gemcitabine with RT
• Oxaliplatin Capecitabine (CapOx) (local funding)

Unknown primary

• Epirubicin Cisplatin Fluorouracil (ECF) 
• Epirubicin Cisplatin Capecitabine (ECX) 
• Gemcitabine (1000) Cisplatin (25)

Cisplatin hydration

• Cisplatin hydration

SACT regimens written by S Coutts