Guidelines for chemotherapy (SACT) are listed below:

Whilst every effort is made to ensure the accuracy of the information in a given regimen it cannot be guaranteed that the regimen is fully up to date, because of the dynamic nature of cancer treatment. Check the regimen details for the specific indication the regimen may be used / funded in. See our disclaimer.

SACT dose bands, diluents and diluent volumes

Diluents, specified diluent volume by agent, flushes:                                                       Diluents, diluent volume required for dose (as per national standard product specifications) plus flushes

Dose bands:

Aflibercept	Dacarbazine	Loncastuximab tesirine	Raltitrexed
Amsacrine	Daratumumab	Melphalan	Ramucirumab
Arsenic trioxide	Daunorubicin	Mesna	Rituximab
Avelumab	Daunorubicin Cytarabine-liposomal (Vyxeos)	Methotrexate (100% dose <30mg)	Romidepsin
Azacitidine	Daunorubicin liposomal	Methotrexate (100% dose 30-900mg)
Belantamab mafodontin	Docetaxel	Methotrexate (100% dose >900mg)	Sacituzumab-govitecan
Bendamustine	Doxorubicin	Mitomycin	Siltuximab
Bevacizumab	Doxorubicin liposomal	Mitoxantrone	Streptozocin
Bleomycin IV	Durvalumab	Mogamulizumab
Bortezomib IV			Talquetamab
Bortezomib SC	Enfortumab vedotin	Nelarabine	Teclistamab
Brentuximab	Epirubicin	Nivolumab	Temozolomide
Busulfan	Eribulin		Thiotepa
	Etopophos	Olaratumab	Topotecan
Cabazitaxel	Etoposide	Oxaliplatin	Trabectedin
Capecitabine			Trastuzumab IV
Carboplatin	Fludarabine	Paclitaxel	Trastuzumab deruxtecan
Carfilzomib	Fluorouracil infusion	Paclitaxel albumin bound	Trastuzumab emtansine
Cetuximab	Fluorouracil syringe	Panitumumab	Treosulfan
Cisplatin	Gemcitabine	Pembrolizumab	Trifluridine-tipiracil
Cladribine (Leustat)	Idarubicin	Pemetrexed
Cladribine (Litak)	Ifosfamide	Pentostatin	Vinblastine
Cyclophosphamide infusion	Inotuzumab	Polatuzumab	Vincristine
Cyclophospamide syringe	Ipilimumab		Vindesine
Cytarabine high dose (>410mg/m2)	Irinotecan		Vinflunine
Cytarabine low dose (<410mg/m2)	Isatuximab		Vinorelbine

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SACT and Immuno-oncology guidelines

• • Immuno-oncology agent Immune-related adverse event clinical guidelines can be found here
  • Anaphylaxis (adults)
  • Antiemetics
  • Blueteq calendar year duration treatments
  • Chemotherapy drugs safe handling and administration (adults) – refer to local Trust policy
  • Chemotherapy home spillage – refer to local Trust policy
  • Chemotherapy (SACT) spillage – refer to local Trust policy
  • Cisplatin hydration
  • Diarrhoea – capecitabine induced

• • Extravasation 
    • Extravasation dexrazoxane (Savene) contact details
  • Glucaparidase (requires Blueteq registration)
  • Haemopoietic Growth Factors Erythropoietin (adults)
  • Haemopoietic Growth Factors GCSF (adults)
  • Methotrexate high dose hydration (interim)
• Oral mucositis
• TVCA Self-administration of subcutaneous systemic anti-cancer treatment (SACT) in the community – Policy June 2025
• UKONS acute oncology initial management guidelines

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SACT non-TV approved regimens

• Request for non TV approved (exceptional use / one off) SACT regimen to be added to ARIA

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Aria user guides

• How to check which regimens exist on Aria
• Aria user (prescriber) task list
• Accepting regimen amendments
• Adding CrCl and EDTA or Tests
• Cumulative doses
• Date changes
• Deferring and discontinuing treatment
• Dose modifications, discontinuing drugs and deleting future cycles
• Drug administration
• Entering diagnosis ICD10, Morphology and Staging
• Entering providers
• Entering Vital Signs, Toxicities, PS and Allergies
• Erroring an administered agent
• Flow sheet
• General information
• Interaction checking
• Intrathecal chemotherapy
• Logging on (V16) post upgrade
• Logging on, switching users or location and exiting Aria
• Opening patient – Proceed to (and user preferences)
• Patient status icons
• Patient tracking
• Pharmacist screening
• Pharmacist verification
• Pharmacy approval and dispensing
• Prescribing chemotherapy, antiemetics (support medicines) and ordering additional cycles
• Provider approval (prescriber’s pending Rx work list)
• Scheduling
• System back up
• Tool bar icons
• User preferences (and opening page – proceed to)
• Visit tab

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SACT data guidance

• Data Cleansing for SACT data upload
• Aria use to ensure SACT data upload compliance

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Clinical trials

• Request sheet for new trial to be added to Aria
• Request sheet for existing trial version to be updated on Aria – download file
• Trials (with version number) on Aria
• Trial regimen Aria set up

 

Best practice

National SACT Sharing Best Practice / Innovation Away Day

The Pan Alliances Breast Cancer Group has come together to share new ways of working in breast cancer service delivery across the country.

As part of this a sharing best practice and innovation away day was held earlier this year and the slides and recordings of presentations are available online.