Chemotherapy (SACT)

Looking for a clinical protocol in a hurry?

Guidelines for chemotherapy (SACT) are listed below:

Whilst every effort is made to ensure the accuracy of the information in a given regimen it cannot be guaranteed that the regimen is fully up to date, because of the dynamic nature of cancer treatment. Check the regimen details for the specific indication the regimen may be used / funded in. See our disclaimer.

SACT dose bands, diluents and diluent volumes

Diluents, specified diluent volume by agent, flushes:                                                        

Diluents, diluent volume required for dose (as per national standard product specifications) plus flushes

Dose banding and rounding:

Parenteral agent dose rounding on Aria (ie not included in dose bands below)

Aflibercept Dacarbazine Loncastuximab tesirine Sacituzumab-govitecan
Amsacrine Daratumumab Melphalan Serplulimab
Arsenic trioxide Daunorubicin Mesna Siltuximab
Avelumab Daunorubicin Cytarabine-liposomal (Vyxeos) Methotrexate (100% dose <30mg) Streptozocin
Azacitidine Daunorubicin liposomal Methotrexate (100% dose 30-900mg)
Docetaxel Methotrexate (100% dose >900mg)
Doxorubicin Mirvetuximab soravtansine Talquetamab
Belantamab mafodontin Doxorubicin liposomal Mitomycin Teclistamab
Bendamustine Durvalumab Mitoxantrone Temozolomide
Bevacizumab Mogamulizumab Thiotepa
Bleomycin IV Enfortumab vedotin Tisotumab vedotin
Bortezomib IV Epirubicin Nelarabine Topotecan
Bortezomib SC Eribulin Trabectedin
Brentuximab Etopophos Olaratumab Trastuzumab IV
Busulfan Etoposide Oxaliplatin Trastuzumab deruxtecan
Trastuzumab emtansine
Cabazitaxel Fludarabine Paclitaxel Treosulfan
Capecitabine Fluorouracil infusion Paclitaxel albumin bound Trifluridine-tipiracil
Carboplatin Fluorouracil syringe Panitumumab
Carfilzomib Gemcitabine Pembrolizumab
Cetuximab Idarubicin Pemetrexed Vinblastine
Cisplatin Ifosfamide Pentostatin Vincristine
Cladribine (Leustat) Inotuzumab Polatuzumab Vindesine
Cladribine (Litak) Ipilimumab Vinflunine
Cyclophosphamide infusion Irinotecan Raltitrexed Vinorelbine
Cyclophospamide syringe Isatuximab Ramucirumab
Cytarabine high dose (>410mg/m2) Rituximab Zanidatamab
Cytarabine low dose (<410mg/m2) Romidepsin

 


SACT and Immuno-oncology guidelines


SACT non-TV approved regimens


Aria user guides


SACT data guidance


Clinical trials

 

Best practice

National SACT Sharing Best Practice / Innovation Away Day

The Pan Alliances Breast Cancer Group has come together to share new ways of working in breast cancer service delivery across the country.

As part of this a sharing best practice and innovation away day was held earlier this year and the slides and recordings of presentations are available online.

Last Updated on 04/06/2026 by admin